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3M™ Polisher ST

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3M™ Polisher ST
3M(TM) Polisher ST family
3M(TM) Polisher ST family
3M(TM) Polisher ST family

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About the product

The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane.

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Product details

The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalised membrane downstream of the functionalised nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.
  • Unaffected by process fluid turbidity up to 40 NTU.
  • The 3M™ Polisher ST is a single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalised membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
  • Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions.
  • Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution.
  • Provides DNA reduction in a salt tolerant (ST) manner compared with conventional Q-functional AEX resins.

Product specifications

Industries
Industries

Biopharmaceutical manufacturing

MicronRating
MicronRating

0.8 μm

OverallDiameterMetric
OverallDiameterMetric

24.1 cm, 4.3 cm

Category Name
Category Name

Chromatography Filters

Net Weight (Metric)
Net Weight (Metric)

10 g, 1.2 kg, 72 g, 15.5 g, 1.8 kg

Filter Technology
Filter Technology

Anion exchange chromatography

Micron Rating
Micron Rating

0.8 μm

OverallDiameterImperial
OverallDiameterImperial

1.69 in, 9.49 in

Product Series
Product Series

Polisher ST

Flow Rate (Metric)
Flow Rate (Metric)

1 ml/min, 340 ml/min, 25 ml/min, 4 ml/min, 1020 ml/min

EndModification
EndModification

Luer Loc

categoryName
categoryName

Chromatography Filters

Flow Rate (Imperial)
Flow Rate (Imperial)

0 gal/min, 0.075 gal/min, 0.001 gal/min, 0.224 gal/min

OverallHeightImperial
OverallHeightImperial

5.98 in

Overall Height (Imperial)
Overall Height (Imperial)

1.89 in, 3.98 in, 1.93 in, 2.32 in

FilterType
FilterType

Single Use

OverallHeightMetric
OverallHeightMetric

10.1 cm, 15.2 cm

Overall Diameter (Imperial)
Overall Diameter (Imperial)

3.03 in, 1.69 in, 9.49 in

FlowRateImperial
FlowRateImperial

0.005 gal/min

Overall Diameter (Metric)
Overall Diameter (Metric)

4.3 cm, 7.7 cm, 24.1 cm

End Modification
End Modification

3/4 in Sanitary Connectors, Luer Loc

Filter Type
Filter Type

Single Use

Application
Application

Anion exchange

Overall Height (Metric)
Overall Height (Metric)

4.8 cm, 4.9 cm, 5.9 cm

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