3M™ Polisher ST
About the product
The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane. The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalized membrane downstream of the functionalized nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.
Product Details
- The 3M™ Polisher ST is single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalized membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
- Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions
- Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution
- Provides DNA reduction in a salt tolerant (ST) manner compared with conventional Q-functional AEX resins
Suggested Applications
- Performance unaffected by process fluid turbidity up to 40 NTU
- Residual DNA removal, when present, in process stream
Product Specifications
| Industries |
Industries
BiopharmaceuticalManufacturing |
| Net Weight (Metric) |
Net Weight (Metric)
100.0000, 15.5000 |
| Filter Technology |
Filter Technology
Anion exchange chromatography |
| Micron Rating |
Micron Rating
0.8000 |
| Product Series |
Product Series
Polisher ST |
| Flow Rate (Metric) |
Flow Rate (Metric)
10.0000, 40.0000 |
| Flow Rate (Imperial) |
Flow Rate (Imperial)
0.0110 |
| Overall Diameter (Imperial) |
Overall Diameter (Imperial)
1.6930 |
| Overall Diameter (Metric) |
Overall Diameter (Metric)
4.3000 |
| End Modification |
End Modification
3/4 in Sanitary Connectors, Luer Loc, 1 1/2 in Sanitary Connectors |
| Filter Type |
Filter Type
Single Use |
| Application |
Application
AnionExchange |
| Overall Height (Metric) |
Overall Height (Metric)
4.8000, 5.9000 |