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3M™ Harvest RC

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3M™ Harvest RC

About the product

The 3M™ Harvest RC Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed as an efficient option for harvesting and clarification of modern cell cultures. Clarification with this chromatographic clarifier offers fewer processing steps, higher yield and lower production time and costs.

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Product name and IDs 3M ID Overall Width (Imperial) Overall Length (Imperial) Overall Length (Metric) Overall Width (Metric) Overall Diameter (Imperial) Overall Diameter (Metric) End Modification Micron Rating Flow Rate (Imperial) Overall Height (Imperial) Overall Height (Metric) Flow Rate (Metric) Filter Type Net Weight (Metric) Application Filter Technology Industries Product Series

3M ID

7100302871

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

4.3700 INCH

Overall Diameter (Metric)

111.0000 MILLIMETER

End Modification

-

Micron Rating

-

Flow Rate (Imperial)

-

Overall Height (Imperial)

6.3400 INCH

Overall Height (Metric)

161.0000 MILLIMETER

Flow Rate (Metric)

-

Filter Type

-

Net Weight (Metric)

-

Application

Harvest and clarification

Filter Technology

-

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100245350

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

1.1400 INCH

Overall Diameter (Metric)

2.9000 CENTIMETER

End Modification

Non Pertinent

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

-

Overall Height (Imperial)

2.4000 INCH

Overall Height (Metric)

6.1000 CENTIMETER

Flow Rate (Metric)

-

Filter Type

Single Use

Net Weight (Metric)

-

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100242700

Overall Width (Imperial)

3.3900 INCH

Overall Length (Imperial)

5.0000 INCH

Overall Length (Metric)

12.7000 CENTIMETER

Overall Width (Metric)

8.6000 CENTIMETER

Overall Diameter (Imperial)

-

Overall Diameter (Metric)

-

End Modification

Non Pertinent

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

-

Overall Height (Imperial)

3.5000 INCH

Overall Height (Metric)

8.9000 CENTIMETER

Flow Rate (Metric)

-

Filter Type

Single Use

Net Weight (Metric)

-

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100241969

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

1.6900 INCH

Overall Diameter (Metric)

4.3000 CENTIMETER

End Modification

Luer-Lok

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0000 GALLON_PER_MINUTE

Overall Height (Imperial)

2.3200 INCH

Overall Height (Metric)

5.9000 CENTIMETER

Flow Rate (Metric)

0.5300 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

14.3000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

3M ID

7100236867

Overall Width (Imperial)

-

Overall Length (Imperial)

-

Overall Length (Metric)

-

Overall Width (Metric)

-

Overall Diameter (Imperial)

3.0300 INCH

Overall Diameter (Metric)

7.7000 CENTIMETER

End Modification

3/4" Sanitary

Micron Rating

0.2000 MICROMETER

Flow Rate (Imperial)

0.0010 GALLON_PER_MINUTE

Overall Height (Imperial)

3.3900 INCH

Overall Height (Metric)

8.6000 CENTIMETER

Flow Rate (Metric)

4.2000 MILLILITER_PER_MINUTE

Filter Type

Single Use

Net Weight (Metric)

75.8000 GRAM

Application

Harvest and clarification

Filter Technology

Anion exchange chromatography

Industries

Biopharmaceutical manufacturing

Product Series

Harvest RC

Product Details

Single-stage chromatographic clarification for manufacturing

3M™ Harvest RC Chromatographic Clarifier

Single-stage chromatographic clarification for manufacturing
3M™ Harvest RC Chromatographic Clarifier encapsulates innovative synthetic fibrous anion exchange (AEX) chromatography media and a 0.2 µm polyether sulfone (PES) membrane. This enables a single-stage clarification process of low to high-density cell culture (>40 million cells per mL) with high product recovery and high fidelity of soluble and insoluble contaminant separation. Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibers. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration. User manuals can be found on hcbgregulatory.3m.com.
Experience predictable scaling from discovery to manufacturing
Discovery phase solutions

Discovery phase solutions

Start your discovery process with lab-scale solutions that enable you to do your job in less time with less complexity.

Production-scale solutions

Production-scale solutions

Advance from lab to production scale predictably with the 3M™ Harvest RC Chromatographic Clarifier portfolio of lab and manufacturing capsules.

Read these peer reviewed publications evaluating 3M™ Harvest RC Chromatographic Clarifier.
Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

See how the 3M™ Harvest RC Chromatographic Clarifier compares as a single stage single-use platform for harvest and clarification.

Single-stage chromatographic clarification reduces cost of protein production

Single-stage chromatographic clarification reduces cost of protein production

See how the 3M™ Harvest RC Chromatographic Clarifier intensifies and reduces cost of non-mAb protein production.

Efficient workflows. Excellent clarity.

3M™ Harvest RC Chromatographic Clarifier, BT500 is the latest addition to the 3M™ Harvest RC Chromatographic Clarifier portfolio. It's a rapid harvesting solution that saves time and steps without the need for a centrifuge.

Speed up the discovery process with 3M™ Harvest RC Chromatographic Clarifier, BT500

Speed up the discovery process with 3M™ Harvest RC Chromatographic Clarifier, BT500

The latest addition to the 3M™ Harvest RC Chromatographic Clarifier portfolio enables you to do your job in less time with less complexity. It’s an easy-to-use, bottle-top vacuum clarifier that delivers high product recoveries and DNA reduction (<500ppb*) through a streamlined workflow.

*Based on 5-8% PCV culture

What could the BT500 lab-scale solution do for you?

What could the BT500 lab-scale solution do for you?

  • Fast processing time (< 10 min.)*
  • High purity by utilizing chromatographic clarification by reducing impurities load on downstream steps
  • High product recoveries through simpler workflow (> 85%)
  • Robust performance across multiple molecules/platforms
  • Easy-to-use, single-step clarification fully eliminating centrifugation
  • Consistent clarified stream quality
  • DNA reduction (<500ppb)*
  • *Based on 5-8% PCV culture

  • Simplification of high cell density cell culture fluid clarification unit operations
  • Remove cells, cell debris and DNA (<500 ppb) from the harvested cell culture fluid
  • Optimized for PCV high density CHO cell culture (5-8% PCV)
  • Replacement of primary, secondary and guard membrane clarification stages
  • Typical product recovery of 95+% (capsules)
  • Synthetic chromatographic harvest media with chemically defined extractables
  • Predictable scaling from discovery to manufacturing
  • Lower total cost of manufacturing compared to centrifugation and depth filtration
  • Lower consumption of buffer and water compared to depth filtration
  • Capsules fit into laboratory to manufacturing scale workflows

Suggested Applications

  • Significant turbidity reduction
  • Single-stage chromatographic clarification
  • Single-stage chromatographic clarification

Product Specifications

Industries
Industries

BiopharmaceuticalManufacturing

Net Weight (Metric)
Net Weight (Metric)

1.1000, 1.6000, 14.3000, 3.4000, 69.2000, 75.8000, 9.8000

Filter Technology
Filter Technology

Anion exchange chromatography

Micron Rating
Micron Rating

0.2000

Product Series
Product Series

Harvest RC

Flow Rate (Metric)
Flow Rate (Metric)

4.2000, 0.5300, 170.0000, 2.7000, 380.0000, 57.0000

Flow Rate (Imperial)
Flow Rate (Imperial)

0.0010, 0.0000, 0.0130, 0.0370, 0.0840, 0.5940

Overall Height (Imperial)
Overall Height (Imperial)

2.0900, 2.2400, 2.3200, 2.4000, 3.3900, 3.5000, 4.0900, 5.9800, 6.3400, 7.9900

Overall Length (Imperial)
Overall Length (Imperial)

5.0000

Overall Diameter (Imperial)
Overall Diameter (Imperial)

17.8000, 3.0300, 9.4900, 1.1400, 1.6900, 4.3700

Overall Width (Metric)
Overall Width (Metric)

8.6000

Overall Length (Metric)
Overall Length (Metric)

12.7000

Overall Diameter (Metric)
Overall Diameter (Metric)

24.1000, 45.2000, 7.7000, 111.0000, 2.9000, 4.3000

End Modification
End Modification

3/4" Sanitary, 1-1/2" Sanitary, Luer-Lok, Non Pertinent

Filter Type
Filter Type

Single Use

Overall Width (Imperial)
Overall Width (Imperial)

3.3900

Application
Application

HarvestAndClarification

Overall Height (Metric)
Overall Height (Metric)

10.4000, 15.2000, 161.0000, 20.3000, 5.3000, 5.7000, 5.9000, 6.1000, 8.6000, 8.9000

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