3M™ Harvest RC Centrate Chromatographic Clarifier

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About the product

Designed to effectively clarify Chinese Hamster Ovary (CHO) cell culture centrates produced by conventional and single-use conical plate (e.g., disc stack) centrifuges, 3M™ Harvest RC Centrate Chromatographic Clarifier is a single-stage chromatography solution that employs a synthetic fibrous anion exchange (AEX) Q-functional chromatography media to enable product recoveries of >95% and cell shear-related impurity reduction.

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Product name and IDs	3M ID	Overall Width (Imperial)	Overall Length (Imperial)	Overall Length (Metric)	Overall Width (Metric)	Overall Diameter (Imperial)	Overall Diameter (Metric)	End Modification	Micron Rating	Flow Rate (Imperial)	Overall Height (Imperial)	Overall Height (Metric)	Flow Rate (Metric)	Filter Type	Net Weight (Metric)	Application	Filter Technology	Industries	Product Series
3M™ Harvest RC, BT500, 6/Case	3M ID 7100302871	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 4.3700 INCH	Overall Diameter (Metric) 111.0000 MILLIMETER	End Modification -	Micron Rating -	Flow Rate (Imperial) -	Overall Height (Imperial) 6.3400 INCH	Overall Height (Metric) 161.0000 MILLIMETER	Flow Rate (Metric) -	Filter Type -	Net Weight (Metric) -	Application Harvest and clarification	Filter Technology -	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, CT15, EMP015HRC2FA, 12/Case	3M ID 7100245350	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 1.1400 INCH	Overall Diameter (Metric) 2.9000 CENTIMETER	End Modification Non Pertinent	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) -	Overall Height (Imperial) 2.4000 INCH	Overall Height (Metric) 6.1000 CENTIMETER	Flow Rate (Metric) -	Filter Type Single Use	Net Weight (Metric) -	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, WP6, EMP006HRC2FA, 4/Case	3M ID 7100242700	Overall Width (Imperial) 3.3900 INCH	Overall Length (Imperial) 5.0000 INCH	Overall Length (Metric) 12.7000 CENTIMETER	Overall Width (Metric) 8.6000 CENTIMETER	Overall Diameter (Imperial) -	Overall Diameter (Metric) -	End Modification Non Pertinent	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) -	Overall Height (Imperial) 3.5000 INCH	Overall Height (Metric) 8.9000 CENTIMETER	Flow Rate (Metric) -	Filter Type Single Use	Net Weight (Metric) -	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, BC4, EMP201HRC2FA, 4/Case	3M ID 7100241969	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 1.6900 INCH	Overall Diameter (Metric) 4.3000 CENTIMETER	End Modification Luer-Lok	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) 0.0000 GALLON_PER_MINUTE	Overall Height (Imperial) 2.3200 INCH	Overall Height (Metric) 5.9000 CENTIMETER	Flow Rate (Metric) 0.5300 MILLILITER_PER_MINUTE	Filter Type Single Use	Net Weight (Metric) 14.3000 GRAM	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, BC25, Sanitary, EMP303HRC2FA, 2/Case	3M ID 7100236867	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 3.0300 INCH	Overall Diameter (Metric) 7.7000 CENTIMETER	End Modification 3/4" Sanitary	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) 0.0010 GALLON_PER_MINUTE	Overall Height (Imperial) 3.3900 INCH	Overall Height (Metric) 8.6000 CENTIMETER	Flow Rate (Metric) 4.2000 MILLILITER_PER_MINUTE	Filter Type Single Use	Net Weight (Metric) 75.8000 GRAM	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, BC1020, EMP533HRC2FA, 1/Case	3M ID 7100236866	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 9.4900 INCH	Overall Diameter (Metric) 24.1000 CENTIMETER	End Modification 3/4" Sanitary	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) 0.0370 GALLON_PER_MINUTE	Overall Height (Imperial) 5.9800 INCH	Overall Height (Metric) 15.2000 CENTIMETER	Flow Rate (Metric) 170.0000 MILLILITER_PER_MINUTE	Filter Type Single Use	Net Weight (Metric) 1.6000 KILOGRAM	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, BC340, EMP513HRC2FA, 1/Case	3M ID 7100236865	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 9.4900 INCH	Overall Diameter (Metric) 24.1000 CENTIMETER	End Modification 3/4" Sanitary	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) 0.0130 GALLON_PER_MINUTE	Overall Height (Imperial) 4.0900 INCH	Overall Height (Metric) 10.4000 CENTIMETER	Flow Rate (Metric) 57.0000 MILLILITER_PER_MINUTE	Filter Type Single Use	Net Weight (Metric) 1.1000 KILOGRAM	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, BC25, Luer, EMP301HRC2FA, 2/Case	3M ID 7100236863	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 3.0300 INCH	Overall Diameter (Metric) 7.7000 CENTIMETER	End Modification Luer-Lok	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) 0.0010 GALLON_PER_MINUTE	Overall Height (Imperial) 2.0900 INCH	Overall Height (Metric) 5.3000 CENTIMETER	Flow Rate (Metric) 4.2000 MILLILITER_PER_MINUTE	Filter Type Single Use	Net Weight (Metric) 69.2000 GRAM	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, BC16000, EMP770HRC2FA, 16 in 7-Cell, 1/Case	3M ID 7100236846	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 17.8000 INCH	Overall Diameter (Metric) 45.2000 CENTIMETER	End Modification 1-1/2" Sanitary	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) 0.5940 GALLON_PER_MINUTE	Overall Height (Imperial) 7.9900 INCH	Overall Height (Metric) 20.3000 CENTIMETER	Flow Rate (Metric) 2.7000 LITER_PER_MINUTE	Filter Type Single Use	Net Weight (Metric) 9.8000 KILOGRAM	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC
3M™ Harvest RC, BC2300, EMP710HRC2FA, 16 in, 1-Cell, 1/Case	3M ID 7100236845	Overall Width (Imperial) -	Overall Length (Imperial) -	Overall Length (Metric) -	Overall Width (Metric) -	Overall Diameter (Imperial) 17.8000 INCH	Overall Diameter (Metric) 45.2000 CENTIMETER	End Modification 1-1/2" Sanitary	Micron Rating 0.2000 MICROMETER	Flow Rate (Imperial) 0.0840 GALLON_PER_MINUTE	Overall Height (Imperial) 2.2400 INCH	Overall Height (Metric) 5.7000 CENTIMETER	Flow Rate (Metric) 380.0000 MILLILITER_PER_MINUTE	Filter Type Single Use	Net Weight (Metric) 3.4000 KILOGRAM	Application Harvest and clarification	Filter Technology Anion exchange chromatography	Industries Biopharmaceutical manufacturing	Product Series Harvest RC

Product Details

3M™ Harvest RC Centrate Chromatographic Clarifier encapsulates innovative synthetic fibrous AEX Q-functional chromatography media combined with an asymmetric Q-functional polyamide membrane with a 0.2 µm qualifying zone. This enables effective single-stage clarification of CHO cell culture centrates produced by conventional and single-use conical plate (e.g., disc stack) centrifuges. Electrostatic interactions with a positively charged ligand immobilized on a fiber matrix and a downstream polyamide membrane capture soluble and insoluble impurities, resulting in efficient retention of a wide range of particles that have not been effectively separated by centrifugation or are produced by cell shear during centrifugation. Specifically, the AEX mechanism enables efficient capture of impurities <0.5 µm that are difficult to capture with traditional depth filtration and membrane filtration.

Cleaner centrate for an improved downstream process

mAb product recovery

The innovative 3M™ Harvest RC Centrate Chromatographic Clarifier effectively clarifies CHO cell culture centrates produced by conventional and single-use conical plate (e.g., disc stack) centrifuges. The single-mode electrostatic separation mechanism and high throughput media enables product recoveries of >95%

Cell shear-related impurity reduction

Achieve high quality and consistent clarified centrate using 3M™ Harvest RC Centrate Chromatographic Clarifier for CHO cell culture centrate. The clarified centrate has low turbidity (<15 NTU), low DNA (< 500 ppb) and the ability to protect a downstream sterile filter (>500 L/m2 for 0.1 μm filter).

Scalability

From lab to manufacturing scale devices, 3M™ Harvest RC Centrate Chromatographic Clarifier provides a predictable and scalable solution aligned to process workflows.

The innovative synthetic fibrous AEX chromatographic clarification media enables a single-stage centrate clarification from CHO cell cultures with high product recovery and high fidelity of soluble and insoluble impurity removal. The 0.2 µm asymmetric Q-functional polyamide membrane, which is downstream of the fibrous chromatographic clarification media, distributes the flow across the AEX media bed and enables the protection of the downstream sterilizing grade membrane filter. Also, the 0.2 µm functionalized polyamide membrane enables simple process endpoint measurement using pressure reading.

Clarify centrate like never before

Separation by charge

Consisting of a range of high-capacity, single-use synthetic chromatographic clarification products that separate by charge, the 3M™ Harvest RC Centrate Chromatographic Clarifier product family was designed with a fiber chromatography media to effectively capture cell shear-related insoluble impurities in the submicron size range that are typically present in centrate feed streams.

Particle size control

3M™ Harvest RC Centrate Chromatographic Clarifier provides effective reduction of a wide range of particle sizes that are typically present in centrate feed streams. The fiber chromatography technology is highly effective at capturing the population of <0.5 µm particles that are difficult to remove using traditional depth filtration.

Robust sterile membrane filter protection

Due to the highly effective chromatographic reduction of soluble and insoluble impurities, 3M™ Harvest RC Centrate Chromatographic Clarifier enables efficient centrate clarification. This allows the effective protection of the final sterilizing grade membrane filter down to 0.1 µm pore size.

Resisting clarification stage particle breakthrough

The Q-functionalized fibrous media and membrane of the 3M™ Harvest RC Centrate Chromatographic Clarifier can prevent particle breakthrough, which can impact membrane filter performance. With wet-laid media present in depth filters, particle breakthrough can occur, creating pressure buildup across the membrane filter stage, which destabilizes the clarification process.

- Single-stage centrate clarification for process compression and streamlining of process development.
- Enables de-risking of clarification process development, scale-up and tech transfer for faster speed to market.
- Synthetic, functionalized fibrous media provides effective soluble impurity removal in centrate, including DNA and cell shear-related submicron particle reduction.
- Predictable performance scalability for consistent centrate clarification at various process scales.
- tThe single-mode electrostatic separation mechanism and high-throughput media enable product recoveries of >95%.
- Provides comparable effluent quality to 3M™ Harvest RC Chromatographic Clarifier for a modern clarification platform.
- tLower consumption of buffer or water compared to depth filtration.
- tAlkaline-resistant capsules for pre-use sanitization.

Suggested Applications

- BC4, BC25, BC170, BC340, BC1020, BC2300 and BC18400: Biopharmaceutical processing applications of aqueous-based pharmaceuticals (drugs) and vaccines in accordance with the product instructions and specifications, cGMP and GLP requirements, where applicable.

Product Specifications

Industries	Industries BiopharmaceuticalManufacturing
Net Weight (Metric)	Net Weight (Metric) 1.1000, 1.6000, 14.3000, 3.4000, 69.2000, 75.8000, 9.8000
Filter Technology	Filter Technology Anion exchange chromatography
Micron Rating	Micron Rating 0.2000
Product Series	Product Series Harvest RC
Flow Rate (Metric)	Flow Rate (Metric) 4.2000, 0.5300, 170.0000, 2.7000, 380.0000, 57.0000
Flow Rate (Imperial)	Flow Rate (Imperial) 0.0010, 0.0000, 0.0130, 0.0370, 0.0840, 0.5940
Overall Height (Imperial)	Overall Height (Imperial) 2.0900, 2.2400, 2.3200, 2.4000, 3.3900, 3.5000, 4.0900, 5.9800, 6.3400, 7.9900
Overall Length (Imperial)	Overall Length (Imperial) 5.0000
Overall Diameter (Imperial)	Overall Diameter (Imperial) 17.8000, 3.0300, 9.4900, 1.1400, 1.6900, 4.3700
Overall Width (Metric)	Overall Width (Metric) 8.6000
Overall Length (Metric)	Overall Length (Metric) 12.7000
Overall Diameter (Metric)	Overall Diameter (Metric) 24.1000, 45.2000, 7.7000, 111.0000, 2.9000, 4.3000
End Modification	End Modification 3/4" Sanitary, 1-1/2" Sanitary, Luer-Lok, Non Pertinent
Filter Type	Filter Type Single Use
Overall Width (Imperial)	Overall Width (Imperial) 3.3900
Application	Application HarvestAndClarification
Overall Height (Metric)	Overall Height (Metric) 10.4000, 15.2000, 161.0000, 20.3000, 5.3000, 5.7000, 5.9000, 6.1000, 8.6000, 8.9000

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3M™ Harvest RC Centrate Chromatographic Clarifier

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