Fiber chromatographic clarification
Equip your process with next-generation technology
Your innovative therapeutics need to reach market quickly, and you can build your process to keep up. Even as recombinant protein development and manufacturing become more complex, you can target key steps for intensification and simplicity. You can also maintain quality output while processing higher cell densities and scaling up or down rapidly. When you choose the right harvest and clarification solutions, you protect your downstream purification processes and your manufacturing facilities’ flexibility and efficiency.
Now you can simplify and streamline your recombinant protein harvest and clarification process with a unified solution platform from Solventum. Our recently expanded 3M™ Harvest RC Chromatographic Clarifier platform now has two products to reduce process steps and provide a solution that integrates into your system infrastructure where you need it most.
You can have consistent, scalable harvest and clarification performance, with no need to change technologies as you go from discovery to production. You can de-risk technology transfers and maintain predictable product quality, as you increase your capacity.
Reimagine biopharmaceutical clarification from size to charge
You can push the boundaries of your clarification process by shifting focus from size to charge. While certain impurities may be a similar size to your desired product, they typically have a different electrical charge at the harvested cell culture pH. That’s where anion exchange (AEX) fiber chromatography comes in. Functionalized with Q-chemistry, the AEX fibrous nonwoven media separates by charge. It effectively captures cells, cell debris, host cell proteins (HCP) and DNA and other contaminants and impurities that are negatively charged, while letting the positively charged molecules of interest to flow through.
AEX fiber chromatography solutions from Solventum can help make your downstream processing easier and more efficient.
One platform, two products: The 3M™ Harvest RC Chromatographic Clarifier platform
Streamline your processes by combining steps into a single solution with the 3M™ Harvest RC Chromatographic Clarifier platform. This single platform offers you two innovative solutions: 3M™ Harvest RC Chromatographic Clarifier and 3M™ Harvest RC Centrate Chromatographic Clarifier. Both feature fiber chromatography technology and can enable you to replace multiple depth filtration steps while increasing your yield of therapeutic product.
They can be seamlessly integrated in your process, for direct harvest and clarification or for post-centrifuge clarification. The efficiencies you gain may help you get to market faster and de-risk technology transfers as you scale.
The 3M™ Harvest RC Chromatographic Clarifier platform provides:
- A platformable and scalable clarification solution
- Solutions from drug discovery, through pre-clinical testing and clinical studies, to commercial production
- Bench top capsules that are available for easy trialing
- Options for direct harvest and clarification or for centrate clarification
- Comparable effluent quality including high product recovery, turbidity reduction, DNA removal and sterile filter protection
See how separating by charge can elevate your process
You can intensify your process and gain efficiencies with our fiber chromatography solutions. Watch now and learn how to integrate the 3M™ Harvest RC Chromatographic Clarifier platform into your process.
A scalable platform to take you from process development to manufacturing
For process scale-up, scale-out and technology transfer from discovery to manufacturing, you need scalable solutions. Get linear scalability with the solutions in the 3M™ Harvest RC Chromatographic Clarifier platform, to help you accelerate process development, simplify manufacturing strategies and improve process economics.
Predictable, high-fidelity clarification across process scales
You can simplify your downstream process development and technology transfer across internal and external manufacturing footprints when you have consistent results. The solutions in the 3M™ Harvest RC Chromatographic Clarifier platform provide comparable soluble and insoluble impurity reduction based on particle size and DNA clearance, whether or not your process uses centrifugation.
How do products in the platform compare?
Rapid fiber chromatography clarification
Time is important in every process. In this video using small benchtop-sized units, you can see how the 3M™ Harvest RC Chromatographic Clarifier BT500 can generate high quality samples in less than 10 minutes.* Watch now to compare the speed of clarification in three different approaches to lab harvesting.
*Based on 5-8% PCV culture.
Discovery phase single-stage chromatographic clarification
Bioprocessing clarification has arrived
You can leverage advanced materials science technology to remove more contaminants earlier in your post-centrifuge process. Watch now to discover the 3M™ Harvest RC Centrate Chromatographic Clarifier.
3M™ Harvest RC Chromatographic Clarifier | 3M™ Harvest RC Centrate Chromatographic Clarifier | |
|---|---|---|
| Type of clarification | Direct clarification | Centrate clarification |
| Technology platform | Quaternary amine (Q) functionalized polypropylene nonwoven |
|
Mechanism | AEX chromatography | AEX chromatography
|
| Materials | Synthetic | Synthetic
|
Feed stream | Direct harvest and clarification | Centrate clarification
|
| Scalability | Linear scalability from lab to multi-capsule commercial production (including screening tools)
| Linear scalability from lab to multi-capsule commercial production
|
| Water flushable | Yes
| Yes
|
| Features |
|
|
| Learn more | View 3M™ Harvest RC Chromatographic Clarifier | View 3M™ Harvest RC Centrate Chromatographic Clarifier (waiting on base sku split) |
Next steps
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