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3M™ Polisher ST, BC1020, 1/Case

Germany,Spain,France,United Kingdom,Italy,Japan,Korea,Netherlands,United States

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3M™ Polisher ST, BC1020, 1/Case

About the product

The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane. The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalized membrane downstream of the functionalized nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.

  • Overall Diameter (Imperial) : 9.4900
  • Overall Diameter (Metric) : 24.1000
  • End Modification : 3/4 in Sanitary Connectors
  • Micron Rating : 0.8000
  • Flow Rate (Imperial) : 0.2240
  • Overall Height (Imperial) : 5.9800
  • Overall Height (Metric) : 15.2000
  • Flow Rate (Metric) : 1020.0000
  • Filter Type : Single Use
  • Net Weight (Metric) : 1.8000
  • Application : Anion exchange
  • Filter Technology : Anion exchange chromatography
  • Industries : Biopharmaceutical manufacturing
  • Product Series : Polisher ST

Product Details

  • The 3M™ Polisher ST is single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalized membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
  • Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions
  • Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution
  • Provides DNA reduction in a salt tolerant (ST) manner compared with conventional Q-functional AEX resins

Suggested Applications

  • Performance unaffected by process fluid turbidity up to 40 NTU
  • Residual DNA removal, when present, in process stream

Product Specifications

Industries
Industries

Biopharmaceutical manufacturing

Net Weight (Metric)
Net Weight (Metric)

1.8000

Filter Technology
Filter Technology

Anion exchange chromatography

Micron Rating
Micron Rating

0.8000

Product Series
Product Series

Polisher ST

Flow Rate (Metric)
Flow Rate (Metric)

1020.0000

Flow Rate (Imperial)
Flow Rate (Imperial)

0.2240

Overall Height (Imperial)
Overall Height (Imperial)

5.9800

Overall Diameter (Imperial)
Overall Diameter (Imperial)

9.4900

Overall Diameter (Metric)
Overall Diameter (Metric)

24.1000

End Modification
End Modification

3/4 in Sanitary Connectors

Filter Type
Filter Type

Single Use

Application
Application

Anion exchange

Overall Height (Metric)
Overall Height (Metric)

15.2000

BP PDP

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