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3M Promogran Prisma Collagen Matrix with ORC and Silver

Unlike any other collagen dressing

3M™ Promogran Prisma™ Collagen Matrix with ORC and Silver, uniquely formulated and proven in randomized controlled trials1-2, is labeled for use with 3M™ ActiV.A.C.™ Therapy, offering a powerful tool for your wound care arsenal. 

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Clinician applying 3M™ Promogran Prisma™ Matrix to patient's heel, TIF File.
Foundations for healing Promogram Matrix Family Resources Explore more Contact us
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Foundations for healing
Promogram Matrix Family
Resources
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Foundations for healing 

Clinician applying 3M™ Promogran Prisma™ Matrix to sacral pressure ulcer

Creating the right conditions for healing is crucial, especially for hard-to-heal wounds. Addressing inflammation and bioburden is an important step. While collagen is effective against matrix metalloproteinases (MMPs), its impact on elastase, another abundant protease, is limited. In vitro studies show that combining Oxidized Regenerated Cellulose (ORC) with collagen has a greater effect than collagen alone in reducing both MMP and elastase activity, both highly predictive indicators of non-healing wounds3-4.

 

Elastase plays a critical role as it's one of the most prevalent proteases in hard-to-heal wounds. It arrives early post-injury, and can damage crucial elements including5-7:

  • Fibronectin: Which aids cell adhesion and migration 
  • Elastin: Which provides tissue elasticity 
  • Growth factors: PDGF and EGF 

3M Promogran Matrix Family: Proven outcomes 

Enhancing patient outcomes is at the heart of our wound care approach, and the 3M™ Promogran™ Matrix Family stands out.

  • 1.74x higher odds to achieve complete healing2 
  • Proven effective in clinical studies and Randomized Controlled Trials (RCT)1-2  
  • Improves overall success rates when applied early8-11  
  • Potential to reduce treatment costs12
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Promogran Prisma Collagen Matrix application video 

Find detailed, step-by-step guidance on how to apply Promogran Prisma Collagen Matrix with ORC and Silver alongside ActiV.A.C. Therapy System for management of certain hard-to-heal wounds. 

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References

  1. Chowdhry S.A, et al. Use of oxidised regenerated cellulose/collagen dressings versus standard of care over multiple wound types:a systematic review and meta-analysis. Int Wound J. 2021.  
  2. Chen Y, Du P, Lv G. A meta-analysis examined the effect of oxidised regenerated cellulose/collagen dressing on the management of chronic skin wounds. Int Wound J. 2023;20(5):1544-1551. doi:10.1111/iwj.14009CHENET AL.1551 
  3. Cullen B, Watt P, Lundqvist C, et al. The role of oxidized regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action. Int J Biochem Cell Biol. 2002; 34(12):1544–1556. 
  4. Serena T, Cullen T, Bayliff S, et al. Defining a new diagnostic assessment parameter for wound care: Elevated protease activity, an indicator of non-healing for targeted treatment. Wound Repair Regen. 2016;24(3):589-595. 
  5. Gibson D, Cullen B, Legerstee R, Harding KG, Schultz G. MMPs made easy. Wounds International. 2009;1(1)1-6. 
  6. Weitz JI, Landmann SL, Crowley KA, Birken S, Morgan FJ. Development of an assay for in vivo human neutrophil elastase activity. Increased elastase activity in patients with alpha 1-proteinase inhibitor deficiency. J Clin Invest. 1986; 78:155-162. doi:10.1172/JCI112545. Cited by: Ferreira AV, Perelshtein I, Perkas N, Gedanken A, Cunha J, Cavaco-Paulo A. Detection of human neutrophil elastase (HNE) on wound dressings as marker of inflammation. Appl Microbiol Biot1echnol. 2017; 101:1443-1454. 
  7. Hasmann A, Gewessler U, Hulla E, et al. Sensor materials for the detection of human neutrophil elastase and cathepsin G activity in wound fluid. Exp Dermatol. 2011; 20(6):508-513. doi: 10.1111/j.1600-0625.2011.01256.x. Cited by: Ferreira AV, Perelshtein I, Perkas N, Gedanken A, Cunha J, Cavaco-Paulo A. Detection of human neutrophil elastase (HNE) on wound dressings as marker of inflammation. Appl Microbiol Biotechnol. 2017; 101:1443-1454. 
  8. Cullen B, et al. Early adoption of collagen/ORC therapies improves clinical outcome. Paper presented at: Wounds UK Harrogate, 2011.  
  9. Gottrup F, Cullen B, Karlsmark T, Bischoff-Mikkelsen M, Nisbet L, Gibson M. Randomized controlled trial on collagen/oxidized regenerated cellulose/silver treatment. Wound Repair & Regeneration. 2013; 21:1-10.  
  10. Veves A, Sheehan P, Pham HT. A randomised controlled trial of Promogran (a collagen/ oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg. 2002; 137(7):822-827.  
  11. Vin, F., Teot, L. and Meaume, S. (2002) The healing properties of Promogran in venous leg ulcers. J Wound Care, 11, 335-341. 
  12. Snyder, R. et al. A Retrospective Study of Sequential Therapy with Advanced Wound Care Products versus Saline Gauze Dressings: Comparing Healing and Cost. Ostomy Wound Management. 2010; 56(11A):9–15. 
  13. Bourdillon KA, Delury C, Cullen B. Biofilms and delayed healing – an in vitro evaluation of silver and iodine containing dressings and their effect on bacterial and human cells. International Wound Journal. 2017. ISSN 1742-4801.