3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule E16E01A90ZB05A, 16 in, 1 cell, 1/Case

The 3M Zeta Plus Encapsulated System consists of three product lines: a pilot system that is ideal for larger scale-up studies, and two systems that are designed for production scale biomanufacturing. The pilot and production systems are comprised of a filter holder, top and bottom manifolds, and the required number of capsules.

The 3M Zeta Plus Encapsulated Systems for production scale biomanufacturing feature an ergonomically designed large holder (Model #16EZB) that is pivoted between horizontal and vertical positions, allowing for convenient loading and unloading, minimal footprint during filtration, minimal fluid spills during unloading, and full utilization of the filter media.

The capsule design features a translucent plastic shell (standard capsules) for easy liquid level detection; a self-guiding locking mechanism for fast and robust capsule-to-capsule connection; and the 3M Zeta Plus depth filter media that provides excellent filtration performance.

About 3M™ Zeta Plus™ ZB Series Media

3M™ Zeta Plus™ Encapsulated Filters with ZB Series Media are optimized for secondary polishing applications in clarification of mammalian cell harvest step and for protection of downstream sterilizing grade membrane filters. Their strong positive charge provides enhanced reduction of negatively charged contaminants compared with a mechanical filtration mechanism alone. In solution cells, cellular debris, endotoxins, and nucleic acids (DNA, RNA) carry a negative charge. 3M applies the positive zeta potential to ZB filter media to create a filter matrix that enhances the capture of negatively charged contaminants for maximum filtration performance. The strong positive charge over a broad pH range makes these filters ideal for cell broth clarification and for protection of downstream membrane filters.

3M Zeta Plus Encapsulated Filters with ZB Series Media are supported with a Regulatory Support File and Certificate of Analysis to ease validation and regulatory submissions. The products are also documented in a Drug Master File (DMF) on record with the US Food and Drug Administration (FDA).

Ergonomically Designed Filter Holders

The process hardware that goes with the single use 3M Zeta Plus capsules is designed with ease of use in mind. Traditional depth filtration systems utilize lenticular style cartridge filters and a vertical filtration flow path to allow easy access to process liquids and efficient utilization of filter media. However, stacking cartridges from bottom to top can be cumbersome, and dismantling the spent cartridges is often labor intensive. Furthermore, fluid spills during the unloading process could be problematic and, in some instances, might expose the operators to the process fluids.

Recognizing the need for a depth filtration system that is fast, easy and clean, 3M designed filter holders (Model #16EZB) that can be pivoted between the horizontal position for loading and unloading the capsules and manifolds, and the vertical position for filtration. Allowing loading and unloading at waist height eliminates the need for operators to lift capsules above their heads and reduces the risk of fluid spills when handling spent capsules. The use of the vertical flow path allows for full media utilization and a small system footprint during filtration.