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3M™ Harvest RC, BT500, 6/Case

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3M™ Harvest RC, BT500, 6/Case

About the product

The 3M™ Harvest RC Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed as an efficient option for harvesting and clarification of modern cell cultures. Clarification with this chromatographic clarifier offers fewer processing steps, higher yield and lower production time and costs.

Details

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  • Overall Diameter (Imperial) : 4.3700
  • Overall Diameter (Metric) : 111.0000
  • Overall Height (Imperial) : 6.3400
  • Overall Height (Metric) : 161.0000
  • Application : Harvest and clarification
  • Industries : Biopharmaceutical manufacturing
  • Product Series : Harvest RC
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Product Details

Single-stage chromatographic clarification for manufacturing

3M™ Harvest RC Chromatographic Clarifier

Single-stage chromatographic clarification for manufacturing
3M™ Harvest RC Chromatographic Clarifier encapsulates innovative synthetic fibrous anion exchange (AEX) chromatography media and a 0.2 µm polyether sulfone (PES) membrane. This enables a single-stage clarification process of low to high-density cell culture (>40 million cells per mL) with high product recovery and high fidelity of soluble and insoluble contaminant separation. Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibers. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration. User manuals can be found on hcbgregulatory.3m.com.
Experience predictable scaling from discovery to manufacturing
Discovery phase solutions

Discovery phase solutions

Start your discovery process with lab-scale solutions that enable you to do your job in less time with less complexity.

Production-scale solutions

Production-scale solutions

Advance from lab to production scale predictably with the 3M™ Harvest RC Chromatographic Clarifier portfolio of lab and manufacturing capsules.

Read these peer reviewed publications evaluating 3M™ Harvest RC Chromatographic Clarifier.
Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

See how the 3M™ Harvest RC Chromatographic Clarifier compares as a single stage single-use platform for harvest and clarification.

Single-stage chromatographic clarification reduces cost of protein production

Single-stage chromatographic clarification reduces cost of protein production

See how the 3M™ Harvest RC Chromatographic Clarifier intensifies and reduces cost of non-mAb protein production.

Efficient workflows. Excellent clarity.

3M™ Harvest RC Chromatographic Clarifier, BT500 is the latest addition to the 3M™ Harvest RC Chromatographic Clarifier portfolio. It's a rapid harvesting solution that saves time and steps without the need for a centrifuge.

Speed up the discovery process with 3M™ Harvest RC Chromatographic Clarifier, BT500

Speed up the discovery process with 3M™ Harvest RC Chromatographic Clarifier, BT500

The latest addition to the 3M™ Harvest RC Chromatographic Clarifier portfolio enables you to do your job in less time with less complexity. It’s an easy-to-use, bottle-top vacuum clarifier that delivers high product recoveries and DNA reduction (<500ppb*) through a streamlined workflow.

*Based on 5-8% PCV culture

What could the BT500 lab-scale solution do for you?

What could the BT500 lab-scale solution do for you?

  • Fast processing time (< 10 min.)*
  • High purity by utilizing chromatographic clarification by reducing impurities load on downstream steps
  • High product recoveries through simpler workflow (> 85%)
  • Robust performance across multiple molecules/platforms
  • Easy-to-use, single-step clarification fully eliminating centrifugation
  • Consistent clarified stream quality
  • DNA reduction (<500ppb)*

  • *Based on 5-8% PCV culture

  • Simplification of high cell density cell culture fluid clarification unit operations
  • Remove cells, cell debris and DNA (<500 ppb) from the harvested cell culture fluid
  • Optimized for PCV high density CHO cell culture (5-8% PCV)
  • Replacement of primary, secondary and guard membrane clarification stages
  • Typical product recovery of 95+% (capsules)
  • Synthetic chromatographic harvest media with chemically defined extractables
  • Predictable scaling from discovery to manufacturing
  • Lower total cost of manufacturing compared to centrifugation and depth filtration
  • Lower consumption of buffer and water compared to depth filtration
  • Capsules fit into laboratory to manufacturing scale workflows

Suggested Applications

  • Significant turbidity reduction
  • Single-stage chromatographic clarification
  • Single-stage chromatographic clarification

Legal

Always follow your user instruction manual.

Product Specifications

Industries
Industries

Biopharmaceutical manufacturing

Overall Height (Imperial)
Overall Height (Imperial)

6.3400

Overall Diameter (Imperial)
Overall Diameter (Imperial)

4.3700

Overall Diameter (Metric)
Overall Diameter (Metric)

111.0000

Product Series
Product Series

Harvest RC

Application
Application

Harvest and clarification

Overall Height (Metric)
Overall Height (Metric)

161.0000

BP PDP

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