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Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

We explored the impact of a novel single-use technology employing chromatographic principle-based clarification for a process-intensified cell line technology. In this study, a 16% economic benefit (£/g) was observed using a single-use chromatographic clarification compared to traditional single-use clarification technology by improving the overall product cost through decreased operational complexity, higher loading capacity, increased product recovery, and higher impurity clearance.

Image of two lab workers, one examining vial of liquid.

Seeking drug manufacturing platform - Can drug platforms keep up with complex new molecules?

As therapies have grown in complexity, some drug manufacturing platforms have lost viability. To address a variety of modalities while continuing to operate efficiently, it is necessary to reinvent how physics and chemistry are utilised within these separation technologies.
Solventum embraces the alignment of our culture with that of customers who pursue high-risk initiatives with a goal of accomplishing truly disruptive outcomes.

Image of a lab worker testing liquid at a bench with a laptop for data entry.

Single-stage chromatographic clarification of Chinese Hamster Ovary cell harvest reduces cost of protein production

The use of the 3M™ Harvest RC Chromatographic Clarifier, a single-stage chromatographic clarification product, is identified as an alternative strategy to a three-stage filtration train. Using bioprocess cost modelling, the overall cost of the clarification process was reduced by 17%–30% through process compression, depending on bioreactor scale.

Btec photoshoot 3M™ Harvest RC Centrate lab workers connecting tubes - 02

3M™ Harvest RC Chromatographic Clarifier platform videos

Harvest RC Chromatographic Clarifier BT500 Comparison

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3M™ Harvest RC Centrate Chromatographic Clarifier How-To Video

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3M™ Harvest RC Centrate Chromatographic Clarifier Analytical Video

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How to Operate the Harvest RC Chromatographic Clarifier BT500

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Biopharmaceutical Harvest and Clarification - Whiteboard

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3M™ Harvest RC Conical Tube CT15 Video

3M™ Polisher ST videos

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How to run a 3M™ Polisher ST trial

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3M Polisher ST White Board shorter video

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3M™ Polisher ST - Replacing Column Performance Across all Process Conditions (1)

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3M™ Polisher ST - Virus Clearance Conquers mAb Solutions (2)

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3M Polisher ST Replacing Chromatography Column at Scale

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Developing Next Gen mAb Process Using 3M Solutions

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