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Chromatographic capture of cells to achieve single stage clarification in recombinant protein purification

We explored the impact of a novel single use technology employing chromatographic principle-based clarification for a process-intensified cell line technology. In this study, a 16% economic benefit ($/g) was observed using a single-use chromatographic clarification compared to traditional single-use clarification technology by improving the overall product cost through decreased operational complexity, higher loading capacity, increased product recovery, and higher impurity clearance.

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Seeking drug manufacturing platform - Can drug platforms keep up with complex new molecules?

As therapies have grown in complexity, some drug manufacturing platforms have lost viability. To address a variety of modalities while continuing to operate efficiently, it is necessary to reinvent how physics and chemistry are utilized within these separation technologies.
3M embraces the alignment of our culture with that of customers who pursue high-risk initiatives with a goal of accomplishing truly disruptive outcomes.

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Single-stage chromatographic clarification of Chinese Hamster Ovary cell harvest reduces cost of protein production

The use of the 3M™ Harvest RC Chromatographic Clarifier, a single-stage chromatographic clarification product, is identified as an alternative strategy to a three-stage filtration train. Using bioprocess cost modeling, the overall cost of the clarification process was reduced by 17%–30% through process compression, depending on bioreactor scale.

Read our recent co-publication with Ambrx
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3M™ Harvest RC Chromatographic Clarifier videos

3M™ Emphaze™ AEX Hybrid Purifier

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3M™ Innovation 3M™ Emphaze™ AEX Hybrid Purifier ; 3M™ Emphaze™ AEX Hybrid Purifier

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